A Novel Option

A Novel Option

In cataract surgery, the use of a nepafenac punctal plug delivery system

(N-PPDS) has proven to be effective in significantly reducing postoperative pain in patients.

This is according to the findings of a recent study* published in the Journal of Cataract and Refractive Surgery.

Researchers evaluated the safety and efficacy of the Evolute (Mati Therapeutics, Austin, Texas, USA)

nepafenac punctal plug delivery system in controlling postoperative ocular pain and inflammation after cataract surgery as part of a phase 2 pilot clinical trial.

A safe and non-invasive punctal plug option The L-shaped punctal plug, also known as tear duct plug, is made of medicalgrade silicone.

The device is placed and removed by the ophthalmologist, optometrist or supervised staff member as an in-office procedure

and delivers a consistent level of medication for up to six weeks of sustained efficacy A Novel Option.

During the first week, which corresponds to peak ocular pain and inflammation,

more therapy is delivered with a gradually tapering drug dose delivered in the second week.

The punctal plugs are noninvasive and easy to insert and remove.

Once inserted, it is cosmetically invisible. However, its presence in the punctum can

be easily confirmed with eversion of the lower lid. After the drug-eluting core is exhausted, the plug is removed.

 “The most important finding of the study was that a punctal plug drug delivery of nepafenac provided sustained release of the nonsteroidal anti-inflammatory drug (NSAID)

and dramatically reduced postoperative cell and flare without the need for a topical NSAID drop,” shared study co-author

Dr. Eric D. Donnenfeld. Safety and efficacy of N-PPDS over placebo A Novel Option

The prospective, multicenter, randomized, double-masked study involved 56 subjects over 22-years-old with expected post-cataract correctable distance vision of 20/30 or better.

A total of 38 eyes received the nepafenac punctal plug delivery system (N-PPDS) compared with 18 eyes that received a placebo punctal plug delivery system.

All eyes underwent routine unilateral cataract surgery with intraocular lens (IOL) implantation.

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